| Double stranded and spirally coiled | Single stranded ,non -helical |
| Purine bases are Adenine (A), Guanine (G). Pyrimidine bases are Cytosine (C) and Thymine (T) | Purine bases are Adenine (A), Guanine (G). Pyrimidine bases are Cytosine (C) and Uracil (U) is in place of Thymine. |
| DNA has equal proportion of purines and pyrimidine. | Purines and pyrimidine are not in equal proportion. |
| DNA is hereditary material of all organisms. | It is not hereditary material except some viruses. |
| It carries genetic information from generations to generations. | RNA participates in protein synthesis. |
| It is found in chromosomes, chloroplasts,and mitochondria. | It is found in nucleolus, cytoplasm,and ribosome. |
| Nucleotides of DNA are called deoxyribonucleotides. | Nucleotides of RNA are called ribonucleotides |
